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Table of Contents

• ↓ Accelerated Epigenetic Aging Correlates with Later Loss of Memory Function
• ↓ Where Next For Present Stem Cell Therapies?
• ↓ Polyamines from the Gut Microbiome Affect Life Span in Flies
• ↓ Healthspan May Not Be a Usefully Robust Metric for Progress in Rejuvenation Biotechnology
• ↓ APOEε2 Pericytes Provide a More Resilient Blood-Brain Barrier
• ↓ The Drive to Class GLP-1 Receptor Agonists as Geroprotective Drugs
• ↓ Top Alternatives to fightaging.org

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"Do you want to live a longer life in good health? Simple practices can make some difference, such as exercise or calorie restriction. But over the long haul all that really matters is progress in medicine: building new classes of therapy to repair and reverse the known root causes of aging. The sooner these treatments arrive, the more lives will be saved. Find out how to help »"

"Aging clocks have yet to fulfill their promise, which is to produce a robust measure of biological aging that can be used to rapidly assess the results of potential therapies to slow or reverse the progression of aging, such as via repair of underlying cell and tissue damage that causes aging. This is because these clocks are produced by machine learning approaches applied to data from a patient population, such as omics data, that changes with age. Exactly why any specific combinations of measures identified in this way, such as the state of DNA methylation at scores of specific CpG sites on the nuclear genome in the case of epigenetic clocks, can predict age or mortality risk is a mystery. There is no way at present to connect a given CpG site or protein expression level or feature in imaging data to what is known of mechanisms of aging. Thus a clock cannot be trusted to assess a new approach to treating aging without calibrating it against that approach in slow, expensive life span studies. Which defeats the point of the exercise."

"One of the ways in which researchers approach this challenge is to gathering as much data as possible for as many clocks as possible, in a search for patterns and understanding that will allow clocks to be better trusted. Prospective memory is the ability to remember to follow through on a previously made plan. Like all forms of memory function, it declines with age as the mechanisms of aging produce progressively greater neurodegeneration in brain tissue. In today's open access paper, researchers report on correlations in existing data between epigenetic age acceleration measured in the 40s and prospective memory dysfunction a decade later. The study wasn't large enough and the approach used to assess memory dysfunction was not robust enough to detect correlations at a given age between epigenetic age acceleration and memory function at that time. This suggests that early midlife is an important foundation for later health."

"Linking epigenetic age acceleration to self-reported daily memory lapses: evidence from the National Study of Daily Experiences"

Key Topics & Focus Areas for fightaging.org:

Accelerated Epigenetic Aging Correlates with Later Loss of Memory Function

Where Next For Present Stem Cell Therapies?

Polyamines from the Gut Microbiome Affect Life Span in Flies

Healthspan May Not Be a Usefully Robust Metric for Progress in Rejuvenation Biotechnology

APOEε2 Pericytes Provide a More Resilient Blood-Brain Barrier

The Drive to Class GLP-1 Receptor Agonists as Geroprotective Drugs