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• ↓ The Max Perutz Labs are dedicated to a mechanistic understanding of fundamental biomedical processes. By analyzing and reconstituting complex biological systems across different scales, our scientists aim to link breakthroughs in basic research to advances in human health.
• ↓ Scientific Facilities
• ↓ From Mechanism to Medicine
• ↓ “In science, truth always wins.”
• ↓ A workplace that values diversity and internationality
• ↓ Inspiring and enabling the next generation
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"The Max Perutz Labs are pleased to welcome Milena Schuhmacher as its newest group leader. Milena will join the Perutz in 2027, bringing a chemical biology toolkit and perspective to the study of lipids and membrane organization. Milena currently leads an independent group at EPFL, the Swiss Federal Institute of Technology Lausanne, where her research focuses on lipid signaling and on developing tools to visualize and manipulate individual lipid species in cells. Working at the interface of chemistry and cell biology, she aims to understand how lipid diversity is translated into specific cellular functions. Her work will further complement the Perutz’s existing research strengths."

"Mega corpus callosum (MCC) syndrome, a rare neurodevelopmental disorder, is associated with mutations in the serine/threonine kinase MAST1, a signaling protein expressed in the brain. However, next to nothing is known about MAST1. In a new PNAS study, first author Sumire Antonioli from the Leonard lab has identified previously unknown components of the signaling cascade and characterized how disease-associated mutations alter MAST1 function. The findings suggest that MAST1 may link actin and microtubule cytoskeleton dynamics during neuronal development."

"Perutz group leader Bojan Žagrović is part of the newly funded Marie Skłodowska-Curie (MSCA) Doctoral Network ‘PhaseCat’, which brings together five academic research groups and two companies across Europe to investigate the catalytic potential of protein-RNA condensates. Coordinated by Wim De Malsche at Vrije Universiteit Brussel in Belgium, the four-year network has a total funding volume of €2.6 million and will support nine PhD researchers, two of them associated with the Žagrović group including one jointly mentored with a group at Vrije Universiteit Brussel."

"Building an autophagosome requires cells to rapidly assemble and expand membranes at the right place and time. In a new study published in Nature Communications, first author Elisabeth Holzer from the Martens lab found that the lipid composition of mammalian precursor membranes differ substantially from their yeast counterparts. The team identified the lipid transport protein ATG2A and ATG8-like proteins on the nascent phagophore membrane as key factors in delivering the phosphatidylinositol (PI) required to drive membrane biogenesis. By clarifying how autophagosome formation is controlled, the findings may help better understand how defects in autophagy contribute to neurodegenerative diseases such as Parkinson’s."

Key Topics & Focus Areas for maxperutzlabs.ac.at:

The Max Perutz Labs are dedicated to a mechanistic understanding of fundamental biomedical processes. By analyzing and reconstituting complex biological systems across different scales, our scientists aim to link breakthroughs in basic research to advances in human health.

Scientific Facilities

From Mechanism to Medicine

“In science, truth always wins.”

A workplace that values diversity and internationality

Inspiring and enabling the next generation